SOFTWARE
Inforna
A small molecule lead identification strategy for RNA targets
The Inforna server is freely available for academic use. Please fill out the software licensing agreement and return a signed copy to SCRPS-DisneyLabAdmin@mail.ufl.edu. A user name and password will then be provided.
A description of Inforna can be found in: Velagapudi SP, Gallo SM, and Disney MD https://disney.scripps.ufl.edu/wp-content/uploads/2020/05/software-licensing-agreement-1.pdf . Sequence-based design of bioactive small molecules that target precursor microRNAs. Nature Chemical Biology, 2014, 10, 291-297, doi: 10.1038/nchembio.1452
microRNA Motif Database
A database of motifs found in human microRNAs
The microRNA database is freely available for academic use. Please fill out the software license agreement and return a signed copy to jspindell@scripps.edu. A user name and password will then be provided.
A description of microRNA motif database can be found in: Liu B, Childs-Disney JL, Znosko BM, Wang D, Fallahi M, Gallo SM, and Disney MD. Analysis of human pre-microRNA secondary structural elements. 2015, in press.
RNA-PSP
Software to identify privileged RNA space using sequence information
Available for download by using the link below.
Descriptions of RNA-PSP can be found in: Paul DJ, Seedhouse SJ, and Disney MD. Two-dimensional combinatorial screening and the RNA Privileged Space Predictor (RNA-PSP) efficiently identify aminoglycoside-RNA hairpin loop interactions. Nucleic Acids Research, (2009), 37, 5894-5907; and
Velagapudi SP, Seedhouse SJ, Disney MD. Structure-activity relationships through sequencing (StARTS) defines optimal and suboptimal RNA motif targets for small molecules. Angewandte Chemie International Edition, English (2010), 49, 3816-3818.
Chem-PSP
Software to identify privilege chemical space that binds RNA motifs
Available for download by using the link below.
A description of Chem-PSP can be found in: Seedhouse SJ, Labuda LP, Disney MD. The Privileged Chemical Space Predictor (PCSP): a computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries. Bioorganic Medicinal Chemistry Letters (2010), 20, 1338-1343.