PUBLICATIONS

2023

187. Komlosh, PG.; Chen. JL.; Childs-Disney, J.; Disney, MD.; Canaani D. Broad-spectrum metastasis suppressing compounds and therapeutic uses thereof in human tumors. Sci Rep. (2023) 13(1):20420. doi: 10.1038/s41598-023-47478-x.PMID: 37990044 Free PMC article

186. Springer, NA.; Meyer, SM.; Taghavi, A.; Benhamou, RI.; Tong, Y.; Childs-Disney, JL.; Disney, MD. Methods for the study of ribonuclease targeting chimeras (RiboTACs). Methods Enzymol (2023) 692:249-298. doi: 10.1016/bs.mie.2023.06.006. Epub 2023 Sep 13.PMID: 37925183

185. Meyer, SM.; Tanaka, T.; Taghavi, A.; Baisden, JT.; Grefe, M.; Disney, MD. Optimization of a Protein-Targeted Medicine into an RNA-Specific Small Molecule. ACS Chem Biol (2023) 18(11):2336-2342. doi: 10.1021/acschembio.3c00476. Epub 2023 Oct 23.PMID: 37870980

184. Sattler, R.; Traynor, BJ.; Robertson, J.; Van Den Bosch, L.; Barmada, SJ.; Svendsen, CN.; Disney, MD.; Gendron, TF.; Wong, PC.; Turner, MR.; Boxer, A.; Babu, S.; Benatar, M.; Kurnellas, M.; Rohrer, JD.; Donnelly, CJ.; Bustos, LM.; Van Keuren-Jensen, K.; Dacks, PA.; Sabbagh, MN.; Attendees of the inaugural C9ORF72 FTD/ALS Summit. Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit. Neurol Ther (2023)12(6):1821-1843. doi: 10.1007/s40120-023-00548-8. Epub 2023 Oct 17.PMID: 37847372 Free PMC article.

183. Suresh, BM.; Tong, Y.; Abegg, D.; Adibekian, A.; Childs-Disney, JL.; Disney, MD. Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity. ACS Chem Biol (2023)18(11):2385-2393. doi: 10.1021/acschembio.3c00363. Epub 2023 Oct 12.PMID: 37824291.

182. Gibaut, QMR.; Bush, JA.; Tong, Y.; Baisden, JT.; Taghavi, A.; Olafson, H.; Yao, X.; Childs-Disney, JL.; Wang, ET.; Disney, MD. Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy. ACS Cent Sci (2023) 9(7):1342-1353. doi: 10.1021/acscentsci.2c01223. eCollection 2023 Jul 26.PMID: 37521782 Free PMC article.

181. Bowles, KR.; Pugh, DA.; Pedicone, C.; Oja, L.; Weitzman, SA.; Liu, Y.; Chen, JL.; Disney, MD.; Goate, AM. Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function. bioRxiv (2023) 2023.06.02.543224. doi: 10.1101/2023.06.02.543224

180. Tong, Y.; Lee, Y.; Liu, X.; Childs-Disney, J. L.; Suresh, B. M.; Benhamou, R. I.; Yang, C.; Li, W.; Costales, M. G.; Haniff, H. S.; Sievers, S.; Abegg, D.; Wegner, T.; Paulisch, T. O.; Lekah, E.; Grefe, M.; Crynen, G.; Van Meter, M.; Wang, T.; Gibaut, Q. M. R.; Cleveland, J. L.; Adibekian, A.; Glorius, F.; Waldmann, H.; Disney, M.D. Programming inactive RNA-binding small molecules into bioactive degraders. Nature (2023) 618(7963): 169-179. doi:10.1038/s41586-023-06091-8. PMCID: PMC10232370.

179. Taghavi, A.; Baisden, J. T.; Childs-Disney, J. L.; Yildirim, I.; Disney, Matthew D. Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies. Nucleic Acids Research (2023) 51(11):5325-5340. doi: 10.1093/nar/gkad403

178. Suresh, B. M.; Taghavi, A.; Childs-Disney, J. L.; Disney, M.D. Fragment-Based Approaches to Identify RNA Binders. Journal of Medicinal Chemistry (2023) 66(10): 6523-6541. doi: 10.1021/acs.jmedchem.3c00034

177. Yang, X.; Childs-Disney, J. L.; Disney, M. D. A meditation on accelerating the development of small molecule medicines targeting RNA. Expert Opinion on Drug Discovery (2023) 18(2): 115-117. doi: 10.1080/17460441.2022.2084528

2022

176. Bush, J. A.; Meyer, S. M.; Fuerst, R.; Tong, Y.; Li, Y.; Benhamou, R. I.; Aikawa, H.; Zanon, P. R. A.; Gibaut, Q. M. R.; Angelbello, A. J.; Gendron, T. F.; Zhang, Y.-J.; Petrucelli, L.; Heick Jensen, T.; Childs-Disney, J. L.; Disney, M. D. A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2) in c9ALS/FTD via the nuclear RNA exosome. Proceedings of the National Academy of Sciences (2022) 119(48): e2210532119. doi: 10.1073/pnas.2210532119.

175. Gibaut, Q. M. R.; Akahori, Y.; Bush, J. A.; Taghavi, A.; Tanaka, T.; Aikawa, H.; Ryan, L. S.; Paegel, B. M.; Disney, M. D. Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion. Journal of the American Chemical Society (2022) 144(48): 21972-21979. doi: 10.1021/jacs.2c08883

174. Meyer, S. M.; Tanaka, T.; Zanon, P. R. A.; Baisden, J. T.; Abegg, D.; Yang, X.; Akahori, Y.; Alshakarchi, Z.; Cameron, M. D.; Adibekian, A.; Disney, M. D. DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC). Journal of the American Chemical Society (2022) 144(46): 21096-21102. doi: 10.1021/jacs.2c07217

173. Suresh, B. M.; Akahori, Y.; Taghavi, A.; Crynen, G.; Gibaut, Q. M. R.; Li, Y.; Disney, M. D. Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells. Journal of the American Chemical Society (2022), 144(45): 20815-20824. doi: 10.1021/jacs.2c08770.

172. Jessica L Childs-Disney, Xueyi Yang, Quentin M R Gibaut, Yuquan Tong, Robert T Batey, Matthew D Disney. Targeting RNA structures with small molecules. Nature Reviews Drug Discovery (2022) Aug 8:1-27. PMCID: PMC9360655

171. Tong, Y.; Gibaut, QMR.; Rouse, W.; Childs-Disney, JL.; Suresh, BM.; Abegg, D.; Choudhary, S.; Akahori, Y.;, Adibekian, A.; Moss, WN.; Disney MD. Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA. J Am Chem Soc (2022) 144(26):11620-11625.

170. Benhamou RI, Suresh BM, Tong Y, Cochrane WG, Cavett V, Vezina-Dawod S, Abegg D, Childs-Disney JL, Adibekian A, Paegel BM, Disney MD. DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor. Proc Natl Acad Sci U S A. (2022) 119(6):e2114971119. PMID: 35110406

169. Ye F, Haniff HS, Suresh BM, Yang D, Zhang P, Crynen G, Teijaro CN, Yan W, Abegg D, Adibekian A, Shen B, Disney MD. Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA. ACS Chem Biol. (2022) 17(2):474-482. PMID: 35044149

168. Benhamou RI, Choudhary S, Lekah E, Tong Y, Disney MD. Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor. ACS Chem Biol. (2022) 17(1):5-10. PMID: 34898169

2021

167. Bush JA, Aikawa H, Fuerst R, Li Y, Ursu A, Chen JL, Khan T, Wagner-Griffin S, Van Meter MJ, Olafson H, McKee KK, Childs-Disney JL, Gendron TF, Zhang Y, Coyne AN, Wang ET, Yildirim I, Wang KW, Petrucelli L, Rothstein JD, Disney MD. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS model. Sci. Transl. Med. (2021) 13(617):eabd599 PMID: 34705518

166. Zhang P, Liu X, Abegg D, Tanaka T, Tong Y, Benhamou RI, Baisden J, Crynen G, Meyer SM, Cameron MD, Chatterjee AK, Adibekian A, Childs-Disney JL, Disney MD. Reprogramming of protein-targeted small-molecule medicines to RNA by ribonuclease recruitment. Journal of the American Chemical Society (2021) 143(33):13044-13055. PMID: 34387474.

165. Disney MD. A few revolutions of the RNA world in ACS publications. Journal of the American Chemical Society (2021) 18;143:12419. PMID: 34369145.

164. Haniff HS, Liu X, Tong Y, Meyer SM, Knerr L, Lemurell M, Abegg D, Aikawa H, Adibekian A, Disney MD. A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype. Cell Chemical Biology (2021) S2451-9456(21)00316-0. PMID: 34320373.

163. Bush JA, Williams CC, Meyer SM, Tong Y, Haniff HS, Childs-Disney JL, Disney MD. Systematically studying the effect of small molecules interacting with RNA in cellular and preclinical models. ACS Chemical Biology (2021) 16(7):1111-1127. PMID: 34166593.

162. Vezina-Dawod S, Angelbello AJ, Choudhary S, Wang KW, Yildirim I, Disney MD. Massively parallel optimization of the linker domain in small molecule dimers targeting a toxic r(CUG) repeat expansion. ACS Medicinal Chemistry Letters (2021) 12, 907-914. PubMed Central PMCID: PMC8201483.

161. Baisden JT, Childs-Disney JL, Ryan LS, Disney MD. Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity. Current Opinion in Chemical Biology (2021) 62:119-129. PMID: 34118759.

160. Disney MD. A glimpse at the glycoRNA world. Cell (2021) 184(12):3080-3081. PMID: 34115968.

159. Wagner-Griffin S, Abe M, Benhamou RI, Angelbello AJ, Vishnu K, Chen JL, Childs-Disney JL, Disney MD. A druglike small molecule that targets r(CCUG) repeats in myotonic dystrophy type 2 facilitates degradation by RNA quality control pathways. Journal of Medicinal Chemistry (2021) 64(12):8474-8485. PMID: 34101465.

158. Saif N. Haify, Ronald A.M. Buijsen, Lucas Verwegen, Lies-Anne W.F.M. Severijnen, Helen de Boer, Valerie Boumeester, Roos Monshouwer, Wong Y. Yang, Michael D. Cameron, Rob Willemsen, Disney MD. Renate K. Hukema, Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation. Hum. Mol. Genet. 2021 30(17): 1632–1648. doi: 10.1093/hmg/ddab143.

2020

153. Meyer SM, Williams CC, Akahori Y, Tanaka T, Aikawa H, Tong Y, Childs-Disney JL, Disney MD. Small molecule recognition of disease-relevant RNA structures. Chemical Society Reviews (2020), 49: 7167-7199. doi: 10.1039/d0cs00560f. PMID: 32975549

152. Ursu A, Childs-Disney JL, Andrews RJ, O’Leary CA, Meyer SM, Angelbello AJ, Moss WN, Disney MD. Design of small molecules targeting RNA structure from sequence. Chemical Society Reviews (2020) 49: 7252-7270. doi: 10.1039/d0cs00455c. PMID: 32935689

151. Haniff HS, Knerr L, Liu X, Crynen G, Boström J, Abegg D, Adibekian A, Lekah E, Wang KW, Cameron MD, Yildirim I, Lemurell M, Disney MD. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nature Chemistry (2020) 12: 952-961. doi: 10.1038/s41557-020-0514-4. PubMed Central PMCID: PMC7571259.

150. Benhamou RI, Vezina-Dawod S, Choudhary S, Won Wang K, Meyer SM, Yildirim I, Disney MD. Macrocyclization of a ligand targeting a toxic RNA dramatically improves potency. Chembiochem (2020) in press. doi: 10.1002/cbic.202000445. PMID: 32649032

149. Benhamou RI, Abe M, Choudhary S, Meyer SM, Angelbello AJ, Disney MD. Optimization of the linker domain in a dimeric compound that degrades an r(CUG) repeat expansion in cells. Journal of Medicinal Chemistry (2020) 63:7827-7839. doi: 10.1021/acs.jmedchem.0c00558. PubMed Central PMCID: PMC7450518.

148. Angelbello AJ, Disney MD. A toxic RNA templates the synthesis of its own fluorogenic inhibitor by using a bio-orthogonal tetrazine ligation in cells and tissues. ACS Chemical Biology (2020) 15:1820-1825. doi: 10.1021/acschembio.0c00417. PubMed Central PMCID: PMC7392402.

147. Ursu A, Childs-Disney JL, Angelbello AJ, Costales MG, Meyer SM, Disney MD. Gini coefficients as a single value metric to define chemical probe selectivity. ACS Chemical Biology (2020) 15:2031-2040. doi: 10.1021/acschembio.0c00486. PubMed Central PMID: PMC7442733.

146. Disney MD, Suresh BM, Benhamou RI, Childs-Disney JL. Progress toward the development of the small molecule equivalent of small interfering RNA.Current Opinions in Chemical Biology (2020) 56:63-71. doi: 10.1016/j.cbpa.2020.01.001. PubMed Central PMCID: PMC7311281.

145. Haniff HS, Knerr L, Chen JL, Disney MD, Lightfoot HL. Target-directed approaches for screening small molecules against RNA targets. SLAS Discovery (2020) 25:869-894. doi: 10.1177/2472555220922802. PubMed Central PMID: PMC7442623.

144. Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park H, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, Fountain MA, Rumbaugh G, Childs-Disney JL, Disney MD. Design, optimization, and study of small molecules that target Tau pre-mRNA and affect splicing. Journal of the American Chemical Society (2020) 142:8706-8727. doi: 10.1021/jacs.0c00768. PubMed Central PMCID: PMC7357857.

143. Todd TW, McEachin ZT, Chew J, Burch AR, Jansen-West K, Tong J, Yue M, Song Y, Castanedes-Casey M, Kurti A, Dunmore JH, Fryer JD, Zhang YJ, San Millan B, Teijeira Bautista S, Arias M, Dickson D, Gendron TF, Sobrido MJ, Disney MD, Bassell GJ, Rossoll W, Petrucelli L. Hexanucleotide repeat expansions in c9FTD/ALS and SCA36 confer selective patterns of neurodegeneration in vivo. Cell Reports (2020) 31:107616. doi: 10.1016/j.celrep.2020.107616. PubMed Central PMCID: PMC7480900.

142. Andrews RJ, Peterson JM, Haniff HS, Chen J, Williams C, Grefe M, Disney MD, Moss WN. An in silico map of the SARS-CoV-2 RNA structurome. bioRxiv (2020) 2020.04.17.045161. doi: 10.1101/2020.04.17.045161. PubMed Central PMCID: PMC7263510.

141. Angelbello AJ, DeFeo ME, Glinkerman CM, Boger DL, Disney MD. Precise targeted cleavage of a r(CUG) repeat expansion in cells by using a small-molecule-deglycobleomycin conjugate. ACS Chemical Biology (2020) 15:849-855. doi: 10.1021/acschembio.0c00036. PubMed Central PMCID: PMC7360342.

140. Liu X, Haniff HS, Childs-Disney JL, Shuster A, Aikawa H, Adibekian A, Disney MD. Targeted degradation of the oncogenic microRNA 17-92 cluster by structure-targeting ligands. Journal of the American Chemical Society, (2020), 142:6970-6982. doi: 10.1021/jacs.9b13159. PubMed Central PMCID: PMC7357852.

139. Costales MG, Childs-Disney JL, Haniff HS, Disney MD. How we think about targeting RNA with small molecules. Journal of Medicinal Chemistry, (2020), 63:8880-8900. doi: 10.1021/acs.jmedchem.9b01927. PubMed Central PMCID: PMC7486258.

138. Benhamou RI, Angelbello AJ, Andrews RJ, Wang ET, Moss WN, Disney MD. Structure-specific cleavage of an RNA repeat expansion with a dimeric small molecule is advantageous over sequence-specific recognition by an oligonucleotide. ACS Chemical Biology, (2020), 15:485-493. doi: 10.1021/acschembio.9b00958. PubMed Central PMCID: PMC7081929.

137. Benhamou RI, Angelbello AJ, Wang ET, Disney MD. A toxic RNA catalyzes the cellular synthesis of its own inhibitor, shunting it to endogenous decay pathways. Cell Chemical Biology, (2020), 27:223-231.e4. doi: 10.1016/j.chembiol.2020.01.003. PubMed Central PMCID: PMC7081931.

136. Costales MG, Aikawa H, Li Y, Childs-Disney JL, Abegg D, Hoch DG, Pradeep Velagapudi S, Nakai Y, Khan T, Wang KW, Yildirim I, Adibekian A, Wang ET, Disney MD. Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer. Proceedings of the National Academy of Sciences (USA), (2020), 117:2406-2411. doi: 10.1073/pnas.1914286117. PubMed Central PMCID: PMC7007575.

135. Zhang P, Park HJ, Zhang J, Junn E, Andrews RJ, Velagapudi SP, Abegg D, Vishnu K, Costales MG, Childs-Disney JL, Adibekian A, Moss WN, Mouradian MM, Disney MD. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA. Proceedings of the National Academy of Sciences (USA), (2020), 117:1457-1467. doi: 10.1073/pnas.1905057117. PubMed Central PMCID: PMC6983430.

2019

134. Ursu A, Vézina-Dawod S, Disney MD. Methods to identify and optimize small molecules interacting with RNA (SMIRNAs). Drug Discovery Today, (2019) 24:2002-2016. doi: 10.1016/j.drudis.2019.06.019. PubMed Central PMCID: PMC6842402.

133. Chen JL, Moss WN, Spencer A, Zhang P, Childs-Disney JL, and Disney MD. The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology. PLoS One, (2019),14:e0219210. doi: 10.1371/journal.pone.0219210. PubMed Central PMCID: PMC6619747.

132. O’Leary CA, Andrews RJ, Tompkins VS, Chen JL, Childs-Disney JL, Disney MD, Moss WN. RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression. PLoS One, (2019), 14:e0213758. doi: 10.1371/journal.pone.0213758. PubMed Central PMCID: PMC6576772.

131. Costales MG, Suresh B, Vishnu K, Disney MD. Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA. Cell Chemical Biology, (2019), 26:1180-1186.e5. doi: 10.1016/j.chembiol.2019.04.008. PubMed Central PMCID: PMC6697612.

130. Disney MD, Velagapudi SP, Li Y, Costales MG, Childs-Disney JL. Identifying and validating small molecules interacting with RNA (SMIRNAs). Methods in Enzymology, (2019), 623:45-66. doi: 10.1016/bs.mie.2019.04.027. PubMed Central PMCID: PMC6628145.

129. Disney MD. Targeting RNA with small molecules to capture opportunities at the intersection of chemistry, biology, and medicine. Journal of the American Chemical Society, (2019), 141:6776-6790. doi: 10.1021/jacs.8b13419. PubMed Central PMCID: PMC6541398.

128. Costales MG, Disney MD. Adding broccoli to the biosensor menu. Cell Chemical Biology, (2019), 26:463-465. doi: 10.1016/j.chembiol.2019.04.004. PubMed Central PMID: 31002799.

127. Angelbello AJ, Rzuczek SG, Mckee KK, Chen JL, Olafson H, Cameron MD, Moss WN, Wang ET, Disney MD. Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model. Proceedings of the National Academy of Sciences (USA), (2019), pii: 201901484. doi: 10.1073/pnas.1901484116. PubMed Central PMCID: PMC6475439.

126. Angelbello AJ, Chen JL, Disney MD. Small molecule targeting of RNA structures in neurological disorders. Annals of the New York Academy of Sciences, (2020), 1471:57-71. doi: 10.1111/nyas.14051. PubMed Central PMCID: PMC6785366.

125. Velagapudi SP, Li Y, Disney MD. A cross-linking approach to map small molecule-RNA binding sites in cells. Bioorganic Medicinal Chemistry Letters, (2019), 29:1532-1536. doi: 10.1016/j.bmcl.2019.04.001. PubMed Central PMCID: PMC6598432.

124. Wang Z-F, Ursu A, Childs-Disney JL, Guertler R, Yang W-Y, Bernat V, Rzuczek SG, Fuerst R, Zhang Y-J, Gendron TF, Dwyer BG, Rice JE, Petrucelli L, and Disney MD. The hairpin form of r(G4C2)exp in c9ALS/FTD is repeat-associated non-ATG translation and a target for bioactive small molecules. Cell Chemical Biology, (2019), 26, 179-190.e12. doi: 10.1016/j.chembiol.2018.10.018. PubMed Central PMCID: PMC6386614.

123. Costales MG, Hoch DG, Abegg D, Childs-Disney JL, Velagapudi SP, Adibekian A, Disney MD. A designed small molecule inhibitor of a non-coding RNA sensitizes HER2 negative cancers to Herceptin. Journal of the American Chemical Society, (2019), 141, 2960-2974. doi: 10.1021/jacs.8b10558. PubMed Central PMCID: PMC6400281

122. Chew J, Cook C, Gendron TF, Jansen-West K, Del Rosso G, Daughrity LM, Castanedes-Casey M, Kurti A, Stankowski JN, Disney MD, Rothstein JD, Dickson DW, Fryer JD, Zhang YJ, Petrucelli L. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy. Molecular Neurodegeneration, (2019), 14, 9. doi: 10.1186/s13024-019-0310-z. PubMed Central PMCID: PMC6377782.

121. Wales DJ, Disney MD, Yildirim I. Computational investigation of RNA A-bulges related to microtubule- associated protein Tau causing frontotemporal dementia and Parkinsonism. Journal of Physical Chemistry B, (2019), 123, 57-65. doi: 10.1021/acs.jpcb.8b09139. PubMed Central PMCID: PMC6465094.

2018

120. Li Y, Disney MD. Precise small molecule degradation of a noncoding RNA identifies cellular binding sites and modulates an oncogenic phenotype. ACS Chemical Biology, (2018), 13, 3065–3071. doi: 10.1021/acschembio.8b00827. PubMed Central PMCID: PMC6340300.

119. Disney MD, Dwyer BG, Childs-Disney JL. Drugging the RNA world. Cold Spring Harbor Perspectives in Biology, (2018), 10, pii: a034769. doi: 10.1101/cshperspect.a034769. PubMed Central PMCID: PMC6211391.

118. Disney MD. Introduction to the symposium in print for Laura Kiessling. Bioorganic & Medicinal Chemistry, (2018), 26:iii. PubMed Central PMID: 30420097.

117. Childs-Disney JL, Tran T, Vummidi BR, Velagapudi SP, Haniff HS, Matsumoto Y, Crynen G, Souther M, Biswas A, Wang Z-F, Tellinghuisen TL, and Disney MD. A massively parallel selection of small molecule-RNA motif binding partners informs the design of an antiviral from sequence. Chem, (2018), 4, 2384-2404. doi: 10.1016/j.chempr.2018.08.003. PubMed Central PMCID: PMC6358276.

116. Velagapudi SP, Costales MG, Vummidi BR, Nakai Y, Angelbello AJ, Tran T, Haniff HS, Matsumoto Y, Wang ZF, Chatterjee AK, Childs-Disney JL, Disney MD. Approved anti-cancer drugs target oncogenic non-coding RNAs. Cell Chemical Biology, (2018), 25, 1086-1094.e7. doi: 10.1016/j.chembiol.2018.05.015. PubMed Central PMCID: PMC6334646.

115. Guan L, Luo Y, Ja WW, Disney MD. Small molecule alteration of RNA sequence in cells and animals. Bioorganic & Medicinal Chemistry Letters, (2018), 28, 2794-2796. doi: 10.1016/j.bmcl.2017.10.034. PubMed Central PMCID: PMC5906209.

114. Disney MD, Janda KD. Introduction. Bioorganic & Medicinal Chemistry Letters, (2018), 28:2661-2662. PubMed Central PMID: 30029841.

113. Haniff HS, Graves A, Disney MD. Selective small molecule recognition of RNA base pairs. ACS Combinatorial Science, (2018), 20, 482-491. doi: 10.1021/acscombsci.8b00049. PubMed Central PMCID: PMC6325646.

112. Costales MG, Matsumoto Y, Velagapudi SP, Disney MD. Small molecule targeted recruitment of a nuclease to RNA. Journal of the American Chemical Society, (2018), 140, 6741-6744. doi: 10.1021/jacs.8b01233. PubMed Central PMCID: PMC6100793.

111. Angelbello AJ, Chen JL, Childs-Disney JL, Zhang P, Wang ZF, Disney MD. Using genome sequence to enable the design of medicines and chemical probes. Chemical Reviews, (2018), 118, 1599-1663. doi: 10.1021/acs.chemrev.7b00504. PubMed Central PMCID: PMC5989578.

110. Angelbello AJ, Disney MD. Bleomycin can cleave an oncogenic noncoding RNA. Chembiochem, (2018), 19, 43-47. doi: 10.1002/cbic.201700581. PubMed Central PMCID: PMC5810124.

2017

109. Chen JL, VanEtten DM, Fountain MA, Yildirim I, Disney MD. Structure and dynamics of RNA repeat expansions that cause Huntington’s disease and myotonic dystrophy Type 1. Biochemistry, (2017), 56, 3463-3474. doi: 10.1021/acs.biochem.7b00252. PubMed Central PMCID: PMC5810133.

108. Disney MD. Inhibiting translation one protein at a time. Trends in Biochemical Sciences, (2017), 42:412-413. PubMed Central PMID: 28522328.

107. Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O’Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian LJ, Lee CW, Yue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW, Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A, Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN, McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A, Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitcheva D, Antognetti G, McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD, Floeter MK, Rothstein JD, Boylan KB, Petrucelli L. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine, (2017), 9, pii: eaai7866. doi: 10.1126/scitranslmed.aai7866. PubMed Central PMCID: PMC5576451.

106. Costales M.G., Childs-Disney J.L., Disney MD. Computational tools for design of selective small molecules targeting RNA: from small molecule microarrays to chemical similarity searching. RNA Therapeutics, Topics in Medicinal Chemistry, (2018), 27:1-16. doi:https://doi.org/10.1007/7355_2016_21.

105. Velagapudi SP, Luo Y, Tran T, Haniff HS, Nakai Y, Fallahi M, Martinez GJ, Childs-Disney JL, Disney MD. Defining RNA-small molecule affinity landscapes enables design of a small molecule inhibitor of an oncogenic non-coding RNA. ACS Central Science, (2017), 3, 205-216. doi: 10.1021/acscentsci.7b00009. PubMed Central PMCID: PMC5364451.

104. Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD. Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit. Journal of the American Chemical Society, (2017), 139, 3446-3455. doi: 10.1021/jacs.6b11273. PubMed Central PMCID: PMC5810126.

103. Rzuczek SG, Colgan LA, Nakai Y, Cameron DM, Furling D, Yasuda R, Disney MD. Precise small-molecule recognition of a toxic CUG RNA repeat expansion. Nature Chemical Biology, (2017), 13, 188-193. doi: 10.1038/nchembio.2251. PubMed Central PMCID: PMC5290590.

102. Haga CL, Velagapudi SP, Childs-Disney JL, Strivelli J, Disney MD, Phinney DG. Rapid generation of miRNA inhibitor leads by bioinformatics and efficient high-throughput screening methods. Methods in Molecular Biology, (2017), 1517, 179-198. PubMed Central PMID: 27924483.

2016

101. Disney, MD and Angelbello, AJ. Rational design of small molecules targeting oncogenic noncoding RNAs from sequence. Accounts of Chemical Research, (2016), 49, 2698-2704. PubMed Central PMCID: PMC5286924.

100. Angelbello AJ, Gonzalez AL, Rzuczek SG, Disney MD. Development of pharmacophore models for small molecules targeting RNA: application to the RNA repeat expansion in myotonic dystrophy type 1. Bioorganic Medicinal Chemistry Letters, (2016), 26, 5792-5796. doi: 10.1016/j.bmcl.2016.10.037. PubMed Central PMCID: PMC5286915.

99. Park H, Tran T, Lee JH, Park H, Disney MD. Controlled dehydration improves the diffraction quality of two RNA crystals. BMC Structural Biology, (2016),16, 19. PubMed Central PMCID: PMC5093936.

98. Yang W-Y, He F, Strack RL, Oh S-Y, Frazer M, Jaffrey SR, Todd PK, Disney MD. Small molecule recognition and tools to study modulation of r(CGG)exp in fragile X-associated tremor ataxia syndrome. ACS Chemical Biology, (2016), 11, 2456-2465. doi: 10.1021/acschembio.6b00147. PubMed Central PMCID: PMC5549791.

97. Disney MD. Chemistry and chemical biology of therapeutically important compounds. Bioorganic Medicinal Chemistry, (2016), 24, 3875. doi: 10.1016/j.bmc.2016.06.049. PubMed Central PMID: 27460698.

96. Disney MD, Winkelsas, A, Velagapudi S, Southern M, Fallahi M, Childs-Disney JL. Inforna 2.0: a platform for the sequence-based design of small molecules targeting structured RNAs. ACS Chemical Biology, (2016), 11, 1720-1728. doi: 10.1021/acschembio.6b00001. PubMed Central PMCID: PMC4912454.

95. Costales MG, Rzuczek SG, Disney MD. Comparison of small molecules and oligonucleotides that target a toxic, non-coding RNA. Bioorganic & Medicinal Chemistry Letters, (2016), 26, 2605-2609. doi: 10.1016/j.bmcl.2016.04.025. PubMed Central PMID: 27117425.

94. Yang W-Y, Gao R, Southern M, Sarkar P, Disney MD. Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10. Nature Communications, (2016), 7, 11647. doi: 10.1038/ncomms11647. PubMed Central PMCID: PMC4895354.

93. Velagapudi SP, Cameron MD, Haga CL, Rosenberg LH, Lafitte M, Duckett D, Phinney DG, Disney MD. Design of a small molecule against an oncogenic non-coding RNA. Proceedings of the National Academy of Sciences of the United States of America, (2016), 113, 5898-5903. doi: 10.1073/pnas.1523975113. PubMed Central PMCID: PMC4889373.

92. Liu B, Childs-Disney JL, Znosko BM, Wang D, Fallahi M, Gallo SM, Disney MD. Analysis of secondary structural elements in human microRNA hairpin precursors. BMC Bioinformatics, (2016), 17, 112. doi: 10.1186/s12859-016-0960-6. PubMed Central PMCID: PMC4772329.

91. Childs-Disney JL, Disney MD. Small molecule targeting of a microRNA associated with hepatocellular carcinoma. ACS Chemical Biology, (2016), 11, 375-380. doi: 10.1021/acschembio.5b00615. PubMed Central PMCID: PMC4856042.

90. Childs-Disney JL, Disney MD. Approaches to validate and manipulate RNA targets with small molecules in cells. Annual Review of Pharmacology and Toxicology, (2016), 56, 123-140. doi: 10.1146/annurev-pharmtox-010715-103910. PubMed Central PMCID: PMC4876813.

2015

89. Rzuczek SR, Southern, M, Disney MD. Studying a drug-like, RNA-focused small molecule library identifies compounds that inhibit RNA toxicity in myotonic dystrophy. ACS Chemical Biology, (2015), 10, 2706-2715. doi: 10.1021/acschembio.5b00430. PubMed Central PMCID: PMC4903160.

88. Garbaccio RM, Johnson DS, Hong J, Disney MD. Preface to 25th anniversary special issue: recent advances in medicinal chemistry and chemical biology. Bioorganic Medicinal Chemistry Letters, (2015), 25, 4714. PubMed Central PMID: 26358161.

87. Haga C, Velagapudi SP, Yang W-Y, Disney MD*, and Phinney DG* (*denotes co-corresponding authors). Small molecule inhibition of miR-544 biogenesis disrupts adaptive responses to hypoxia by modulating ATM-mTOR signaling. ACS Chemical Biology, (2015), 10, 2267-2276. doi: 10.1021/acschembio.5b00265. PubMed Central PMCID: PMC4876818.

86. Yildirim I, Chakraborty D, Disney MD, Wales DJ, Schatz GC. Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1. Journal of Chemical Theory and Computation, (2015), 11, 4943-4958. doi: 10.1021/acs.jctc.5b00728. PubMed Central PMCID: PMC4606397.

85. Bernat V, Disney MD. RNA structures as mediators of neurological diseases and as drug targets. Neuron, (2015), 87, 28-46. doi: 10.1016/j.neuron.2015.06.012. PubMed Central PMCID: PMC4508199.

84. Park H, Gonzalez AL, Yildirium, I, Tran T, Lohman JR, Disney MD. Crystallographic and computational analysis of an AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10). Biochemistry, (2015), 54, 3851-3859. doi: 10.1021/acs.biochem.5b00551. PubMed Central PMCID: PMC4876817.

83. Yang WY, Wilson HD, Velagapudi S, Disney MD. Inhibition of non-ATG translational events in cells via covalent small molecules targeting RNA. Journal of the American Chemical Society, (2015), 137, 5336-5345. doi: 10.1021/ja507448y. PubMed Central PMCID: PMC4856029.

82. Velagapudi SP, Vummidi BR, Disney MD. Small molecule chemical probes of microRNA function. Current Opinion of Chemical Biology, (2015), 24, 97-103. doi: 10.1016/j.cbpa.2014.10.024. PubMed Central PMCID: PMC4382669.

2014

81. Rzuczek SG, Park H, and Disney MD. A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor. Angewandte Chemie International Edition in English, (2014), 53, 10956-10959. doi: 10.1002/anie.201406465. PubMed PMID: 25164984.

80. Luo Y and Disney MD. Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA. ChemBioChem, (2014), 15, 2041-2044. doi: 10.1002/cbic.201402069. PubMed Central PMCID: PMC4334360.

79. Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang W-Y, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Boeve BF, Dickson D, Floeter MK, Traynor BJ, Morelli C, Ratti A, Silani V, Rademakers R, Brown RH, Rothstein JD, Boylan KB, Petrucelli L*, and Disney MD*. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron, (2014), 83, 1043-1050. doi: 10.1016/j.neuron.2014.07.041. PubMed Central PMCID: PMC4232217.

78. Hoskins J, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, and Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Research, (2014), 42, 6591-6602. doi: 10.1093/nar/gku275. PubMed Central PMCID: PMC4041448.

77. Tran T, Childs-Disney JL, Liu B, Guan L, Rzuczek S, and Disney MD. Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides. ACS Chemical Biology, (2014), 9, 904-912. doi: 10.1021/cb400875u. PubMed Central PMCID: PMC4287843.

76. Velagapudi SP, Gallo SM, and Disney MD. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nature Chemical Biology, (2014), 10, 291-297. doi: 10.1038/nchembio.1452. PubMed Central PMCID: PMC3962094.

75. Velagapudi SP and Disney MD. Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. Chemical Communications, (2014), 50, 3027-3029. doi: 10.1039/c3cc00173c. PubMed Central PMCID: PMC4040211.

74. Colak D, Zaninovic N, Cohen MS, Rosenwaks Z, Yang WY, Gerhardt J, Disney MD, and Jaffrey SR. Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome. Science, (2014), 343, 1002-1005. doi: 10.1126/science.1245831. PubMed Central PMCID: PMC4357282.

73. Childs-Disney JL, Yildirim I, Park H, Lohman JR, Guan L, Tran T, Sarkar P, Schatz GC, and Disney MD. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity. ACS Chemical Biology, (2014), 9, 538-550. doi: 10.1021/cb4007387. PubMed Central PMCID: PMC3944380.

72. Disney MD, Yildirum I, and Childs-Disney JL. Methods to enable the design of bioactive small molecules targeting RNA. Organic & Biomolecular Chemistry, (2014), 12, 1029-1039. doi: 10.1039/c3ob42023j. PubMed Central PMCID: PMC4020623.

2013 – 1999

71. Disney MD. Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts. Drug Discovery Today, (2013), 18, 1228-1236. doi: 10.1016/j.drudis.2013.07.024. PubMed Central PMCID: PMC3849211.

70. Strack RL, Disney MD, and Jaffrey SR. A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat RNA. Nature Methods, (2013), 10, 1219-1224. doi: 10.1038/nmeth.2701. PubMed Central PMCID: PMC3852148.

69. Rzuczek SG, Gao Y, Tang Z-Z, Thornton CA, Kodadek T, and Disney MD. Features of modularly assembled compounds that impart bioactivity against an RNA target. ACS Chemical Biology, (2013), 8, 2312-2321. doi: 10.1021/cb400265y. PubMed Central PMCID: PMC3876286.

68. Velagapudi SP and Disney MD. Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing. Bioorganic Medicinal Chemistry, (2013), 21, 6132-6138. doi: 10.1016/j.bmc.2013.04.072. PubMed Central PMCID: PMC3789863.

67. Guan L and Disney MD. Covalent small molecule-RNA complex formation enables cellular profiling of small molecule-RNA interactions. Angewandte Chemie International Edition in English, (2013), 52, 10010-10013. doi: 10.1002/anie.201301639. PubMed Central PMCID: PMC3876275.

66. Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, and Charlet- Berguerand N. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Reports, (2013), 3, 869-880. doi: 10.1016/j.celrep.2013.02.004. PubMed Central PMCID: PMC3639429.

65. Yildirim I, Park H, Disney MD, and Schatz GC. A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations. Journal of the American Chemical Society, (2013), 135, 3528-3538. doi: 10.1021/ja3108627. PubMed Central PMCID: PMC3625063.

64. Guan L and Disney MD. Small-molecule-mediated cleavage of RNA in living cells. Angewandte Chemie International Edition in English, (2013), 52, 1462-1465. doi: 10.1002/anie.201206888. PubMed Central PMCID: PMC3711026.

63. Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, and Disney MD. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications, (2013), 4, 2044. doi: 10.1038/ncomms3044. PubMed Central PMCID: PMC3710115.

62. Childs-Disney JL, Parkesh R, Nakamori M, Thornton CA, and Disney MD. Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. ACS Chemical Biology, (2012), 7, 1984-1993. doi: 10.1021/cb3001606. PubMed Central PMCID: PMC3528830.

61. Velagapudi SP, Pushechnikov A, Labuda LP, French JM, and Disney MD. Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening. ACS Chemical Biology, (2012), 7, 1902-1909. doi: 10.1021/cb300213g. PubMed Central PMCID: PMC3500435.

60. Disney MD, Liu B, Yang WY, Sellier C, Tran T, Charlet-Berguerand N, and Childs-Disney JL. A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome. ACS Chemical Biology, (2012), 7, 1711-1718. doi: 10.1021/cb300135h. PubMed Central PMCID: PMC3477254.

59. Childs‐Disney JL, Hoskins J, Rzuczek S, Thornton CA, and Disney MD. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS Chemical Biology, (2012), 7, 856-862. doi: 10.1021/cb200408a. PubMed Central PMCID: PMC3356481.

58. Kumar A, Parkesh R, Sznajder LJ, Childs-Disney JL, Sobczak K, and Disney MD. Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts. ACS Chemical Biology, (2012), 7, 496-505. doi: 10.1021/cb200413a. PubMed Central PMCID: PMC3306454.

57. Parkesh R, Childs‐Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, and Disney MD. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. Journal of the American Chemical Society, (2012), 134, 4731-4742. doi: 10.1021/ja210088v. PubMed Central PMCID: PMC3306011.

56. Guan L and Disney MD. Recent advances in developing small molecules targeting RNA. ACS Chemical Biology, (2012), 7, 73-86. doi: 10.1021/cb200447r. PubMed PMID: 22185671.

55. Tran T and Disney MD. Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations. Nature Communications, (2012), 3, 1125. doi: 10.1038/ncomms2119. PubMed Central PMCID: PMC3533436.

54. Disney MD. Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray. Methods in Molecular Biology, (2012), 808, 303-320. doi: 10.1007/978-1-61779-373-8_21. PubMed Central PMCID: PMC3809005.

53. Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles K, and Disney MD. Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations. Biochemistry, (2011), 50, 9928-9935. doi: 10.1021/bi2013068. PubMed Central PMCID: PMC3218087.

52. Childs-Disney JL, Tsitovich PB, and Disney MD. Using modularly assembled ligands to bind RNA internal loops separated by different distances. ChemBioChem, (2011), 19, 2143-2146. doi: 10.1002/cbic.201100298. PubMed Central PMCID: PMC3378996.

51. Kumar A, Fang P, Park H, Guo M, Nettles KW, and Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. ChemBioChem, (2011), 12, 2140-2142. doi: 10.1002/cbic.201100337. PubMed Central PMCID: PMC3379549.

50. Velagapudi SP and Disney MD. Identifying and characterizing RNA-ligand interactions using 2- dimensional combinatorial screening and structure-activity relationships through sequencing. In Methods for Studying Nucleic Acid/Drug Interactions, (2012), CRC Press; Taylor & Francis Group, Boca Raton, FL, ISBN-10: 1439839735, ISBN-13: 978-1439839737.

49. Lee MM, French JM, and Disney MD. Influencing uptake and localization of aminoglycoside-functionalized peptoids. Molecular Biosystems, (2011), 7, 2441-2451. doi: 10.1039/c1mb05074e. PubMed Central PMCID: PMC3135690.

48. Velagapudi SP, Seedhouse S, French J, and Disney MD. Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. Journal of the American Chemical Society, (2011), 133, 10111-10118. doi: 10.1021/ja200212b. PubMed Central PMCID: PMC3126894.

47. Tran T and Disney MD. Molecular recognition of 6’-N-5-hexynoate kanamycin A and RNA 1×1 internal loops containing CA mismatches. Biochemistry, (2011), 50, 962-969. doi: 10.1021/bi101724h. PubMed Central PMCID: PMC3106427.

46. Parkesh R, Fountain M, and Disney MD. NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)2 reveal a dynamic UU internal loop found in myotonic dystrophy type 1. Biochemistry, (2011), 50, 599-601. doi: 10.1021/bi101896j. PubMed Central PMCID: PMC3031998.

45. Tsitovich PB, Pushechnikov A, French JM, and Disney MD. A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity. ChemBioChem (2010), 11, 1656-1660. doi: 10.1002/cbic.201000300. PubMed Central PMCID: PMC3016878.

44. Velagapudi SP, Seedhouse SJ, and Disney MD. Structure-activity relationships through sequencing (StARTS) defines optimal and suboptimal RNA motif targets for small molecules. Angewandte Chemie International Edition in English (2010), 49, 3816-3818. doi: 10.1002/anie.200907257. PubMed Central PMCID: PMC3021749.

43. Tran T and Disney MD. Two-dimensional combinatorial screening of a bacterial rRNA A-site- like motif library: defining privileged asymmetric internal loops that bind aminoglycosides. Biochemistry (2010), 49, 1833-1842. doi: 10.1021/bi901998m. PubMed Central PMCID: PMC2846769.

42. Seedhouse SJ, Labuda LP, and Disney MD. The Privileged Chemical Space Predictor (PCSP): a computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries. Bioorganic & Medicinal Chemistry Letters (2010), 20, 1338-1343. doi: 10.1016/j.bmcl.2010.01.017. PubMed Central PMCID: PMC2825671.

41. Disney MD, Lee MM, Pushechnikov A, and Childs-Disney JL. The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies. ChemBioChem (2010), 11, 375-382. doi: 10.1002/cbic.200900716. PubMed Central PMCID: PMC2848078.

40. Aminova O and Disney MD. A microarray-based method to perform nucleic acid selections. Methods in Molecular Biology, (2010), 669, 209-224. doi: 10.1007/978-1-60761-845-4_17. PubMed Central PMCID: PMC3840795.

39. Lee MM, Childs-Disney JL, Pushechnikov A, French JM, Sobczak K, Thornton CA, and Disney MD. Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy. Journal of the American Chemical Society (2009), 131, 17464-17472. doi: 10.1021/ja906877y. PubMed Central PMC2801143.

38. Paul DJ, Seedhouse SJ, and Disney MD. Two-dimensional combinatorial screening and the RNA Privileged Space Predictor (RNA-PSP) efficiently identify aminoglycoside-RNA hairpin loop interactions. Nucleic Acids Research, (2009), 37, 5894-5907. doi: 10.1093/nar/gkp594. PubMed Central PMCID: PMC2761267.

37. Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French, JM, Thornton CA, and Disney MD. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. Journal of the American Chemical Society, (2009), 131, 9767-9779. doi: 10.1021/ja9020149. PubMed Central PMCID: PMC2731475.

36. Lee MM, Pushechnikov A, and Disney MD. Rational and modular design of potent ligands targeting the RNA that causes myotonic muscular dystrophy 2. ACS Chemical Biology, (2009), 4, 345-355. doi: 10.1021/cb900025w. PubMed Central PMCID: PMC2748256.

35. Pushechnikov A and Disney MD. Dihydro-2(3H)-thiophenimine hydrochloride. Electronic Encyclopedia of Reagents for Organic Reagents (e-EROS), (2009), doi: 10.1002/047084289X.rn01096.

34. Labuda LP, Pushechnikov A, and Disney MD. Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron. ACS Chemical Biology, (2009), 4, 299-307. doi: 10.1021/cb800313m. PubMed Central PMCID: PMC2777746.

33. Aminova O, Paul DJ, Childs-Disney JL, and Disney MD. Two-dimensional combinatorial screening identifies specific 6’ acylated kanamycin A- and 6’ acylated neamine-RNA hairpin interactions. Biochemistry, (2008), 47, 12670-12679. doi: 10.1021/bi8012615. PubMed Central PMCID: PMC2681321.

32. Disney MD. Short circuiting RNA splicing. Nature Chemical Biology, (2008), 4, 723-724.

31. Barrett OJ, Pushechnikov A, Wu M, and Disney MD. Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray. Carbohydrate Research, (2008), 343, 2924-2931. doi: 10.1016/j.carres.2008.08.018. PubMed Central PMCID: PMC2783256.

30. Disney MD. Book Review: Biochips as pathways to drug discovery. ChemMedChem (2008), 3, 363.

29. Disney MD, Labuda LP, Paul DJ, Poplawski SG, Pushechnikov A, Tran T, Velagapudi SP, Wu M, and Childs-Disney JL. Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. Journal of the American Chemical Society, (2008), 130, 11185‐11194. doi: 10.1021/ja803234t. PubMed PMID: 18652457.

28. Childs-Disney JL and Disney MD. A simple ligation-based method to increase the information density in sequencing experiments used to deconvolute nucleic acid selections. RNA, (2008), 14, 390‐394. doi:10.1261/rna.576908. PubMed Central PMCID: PMC2212251.

27. Childs-Disney JL, Wu M, Pushechnikov A, Aminova O, and Disney MD. A small molecule microarray platform to select RNA internal loop-ligand interactions. ACS Chemical Biology (2007), 2, 745‐754. doi: 10.1021/cb700174r. PubMed PMID: 17975888.

26. Disney MD and Barrett OJ. An aminoglycoside microarray platform for directly monitoring and studying resistance. Biochemistry (2007), 46, 11223-11230. doi: 10.1021/bi701071h. PubMed PMID: 17867707.

25. Disney MD and Childs-Disney JL. “Supra”molecular recognition of Galectin-1. Chemistry & Biology (2007), 14, 1095-1097.

24. Disney MD and Childs-Disney JL. Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6’-N-acylated kanamycin A. ChemBioChem, (2007), 8, 649-656. doi: 10.1002/cbic.200600569. PubMed PMID: 17394189.

23. Barrett OJ, Childs JL, and Disney MD. Chemical microarrays to identify ligands that bind pathogenic cells. ChemBioChem, (2006), 7, 1882-1885. doi: 10.1002/cbic.200600260. PubMed PMID: 17009274.

22. Brun MA, Disney MD, and Seeberger PH. Miniaturization of microwave-assisted carbohydrate functionalization to create oligosaccharide microarrays. ChemBioChem, (2006), 7, 421-424. doi: 10.1002/cbic.200500361. PubMed PMID: 16444768.

21. Kehr JC, Zilliges Y, Springer A, Disney MD, Ratner DD, Bouchier C, Seeberger PH, de Marsac NT, and Dittmann E. A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Molecular Microbiology, (2006), 59, 893-906. doi: 10.1111/j.1365- 2958.2005.05001.x. PubMed PMID: 16420359.

20. Disney MD, Hook D, Namoto K, Seeberger PH, and Seebach D. N-linked glycosylated beta-peptides are resistant to degradation by glycoamidase A. Chemistry and Biodiversity, (2005), 2, 1624-1634. doi: 10.1002/cbdv.200590132. PubMed PMID: 17191959.

19. Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, and Gigliotti F. Activity of Hoechst 33258 against Pneumocystis carinii, f. sp. muris, Candida albicans, and Candida dubliniensis. Antimicrobial Agents Chemotherapy, (2005), 49, 1326-1330. doi: 10.1128/AAC.49.4.1326-1330.2005. PubMed Central PMCID: PMC1068638.

18. Disney MD, Childs JL, and Turner DH. Hoechst 33258 inhibits group I intron self-splicing by affecting RNA folding. ChemBioChem, (2004), 5, 1647-1652. doi: 10.1002/cbic.200400159. PubMed PMID: 15532034

17. Disney MD and Seeberger PH. The use of carbohydrate microarrays to study carbohydrate- cell interactions and to detect pathogens. Chemistry and Biology, (2004), 11, 1701-1707. doi: 10.1016/j.chembiol.2004.10.011. PubMed PMID: 15610854.

16. Disney MD, Zheng J, Swager T, and Seeberger PH. Detection of bacteria with carbohydrate- functionalized fluorescent polymers. Journal of the American Chemical Society, (2004), 126, 13343-13346. doi: 10.1021/ja047936i. PubMed PMID: 15479090.

15. Ratner DM, Adams EW, Disney MD, and Seeberger PH. Tools for glycomics: mapping interactions of carbohydrates in biological systems. ChemBioChem, (2004), 5, 1375-1383. doi: 10.1002/cbic.200400106. PubMed PMID: 15457538.

14. Disney MD and Seeberger PH. Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins. Chemistry-A European Journal, (2004), 10, 3308-3314. doi: 10.1002/chem.200306017. PubMed PMID: 15224340.

13. Mathews DH, Disney MD, Childs JL, Schroeder SJ, Zucker M, and Turner DH. Incorporating chemical modification restraints into a dynamic programming algorithm for prediction of RNA secondary structure. Proceedings of the National Academy of Sciences USA, (2004), 101, 7287-7292. doi: 10.1073/pnas.0401799101. PubMed Central PMCID: PMC409911.

12. Disney MD, Magnet S, Blanchard JS, and Seeberger PH. Aminoglycoside microarrays to study antibiotic resistance. Angewandte Chemie International Edition, (2004), 43, 1591-1594. doi: 10.1002/anie.200353236. PubMed PMID: 15022242.

11. Disney MD, Childs JL, and Turner DH. New approaches to targeting RNA with oligonucleotides: Inhibition of group I intron self-splicing. Biopolymers, (2004), 73, 151-161. doi: 10.1002/bip.10520. PubMed PMID: 14691946.

10. Disney MD and Seeberger PH. Carbohydrate arrays as tools for the glycomics revolution. Drug Discovery Today: TARGETS, (2004), 3, 151-158. doi: 10.1016/S1741-8372(04)02443-0.

9. Du H, Disney MD, Miller BL, and Krauss TD. Hybridization-based unquenching of DNA hairpins on Au surfaces: Prototypical “molecular beacon” biosensors. Journal of the American Chemical Society, (2003), 125, 4012-4013. doi: 10.1021/ja0290781. PubMed PMID: 12670198.

8. Disney MD, Haidaris, CG, and Turner DH. Uptake and antifungal activity of oligonucleotides in Candida albicans. Proceedings of the National Academy of Sciences USA, (2003), 100, 1530-1534. doi: 10.1073/pnas.0337462100. PubMed Central PMCID: PMC149866.

7. Childs JL, Disney MD, and Turner DH. Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing. Proceedings of the National Academy of Sciences USA, (2002), 99, 11091-11096. doi: 10.1073/pnas.172391199. PubMed Central PMCID: PMC123215.

6. Disney MD and Turner DH. Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5′ exon and lower the KM for guanosine. Biochemistry, (2002), 41, 8113-8119. doi: 10.1021/bi020102x. PubMed PMID: 12069604.

5. Disney MD, Matray T, Gryaznov SM, and Turner DH. Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2′ O-methyl hexanucleotides. Biochemistry, (2001), 40, 6520-6526. doi: 10.1021/bi002009j. PubMed PMID: 11371215.

4. Disney MD, Haidaris CG, and Turner DH. Recognition elements for 5′ exon substrate binding to the Candida albicans group I intron. Biochemistry, (2001), 40, 6507-6519. doi: 10.1021/bi002008r. PubMed PMID: 11371214.

3. Disney MD, Gryaznov SM, and Turner DH. Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron. Biochemistry, (2000), 39, 14269-14278. doi: 10.1021/bi001345x. PubMed PMID: 11087376.

2. Disney MD, Testa SM, and Turner DH. Targeting a Pneumocystis carinii group I intron with methylphosphonate oligonucleotides: backbone charge is not required for binding or reactivity. Biochemistry, (2000), 39, 6991-7000. doi: 10.1021/bi992937m. PubMed PMID: 10841781.

1. Testa SM, Disney MD, Turner DH, and Kierzek R. Thermodynamics of RNA-RNA duplexes with 2- or 4-thiouridines: implications for antisense design and targeting a group I intron. Biochemistry, (1999), 38, 16655-16662. doi: 10.1021/bi991187d. PubMed PMID: 10600128.